Physiochemical properties, drugs

Distribution is an important aspect of a drug s pharmacokinetic profile. The structural and physiochemical properties of a drug determine the extent of... 

Jackson, M. R., Balogh, M. P. and Potts, W. B., An Interactive Physiochemical Property Profiling Software for Early Candidate Analysis in Drug Discovery, American Society for Mass Spectrometry 2003 Conference Abstract, Montreal, Canada, 2003. 

The fate of a drag in vivo is dictated by a variety of physiochemical properties, including size, lipophilicity, and charge. These properties determine how a drag is absorbed into the blood, distributed throughout the body, metabolized, and eventually eliminated. While movement of a drug molecule can occur through simple diffusion, there are many transporter proteins expressed on cell membranes to assist... 

Wenlock, M. C., Austin, R. P., Barton, R, Davis, A. M., and Leeson, P. D. (2003). A comparison of physiochemical property profiles of development and marketed oral drugs. Journal of Medicinal Chemistry 46,1250-1256. 

Edwards, M. P., Price, D. A. Role of Physiochemical Properties and Ligand Lipophilicity Efficiency in Addressing Drug Safety Risks. Annu. Rep. Med. Chem. 2010, 45, 381-391. 

Diversity is typically measured using a distance-based or cell-based method cost is typically given as reactant cost/gm and physiochemical properties such as AMW are typically measured as the difference in the distribution of the property in the library compared to the distribution of the same property in a collection of known drugs. The weights, wl5 w2j w3> are user-defined and are typically set so that diversity is maximized, while the cost and physicochemical properties are minimized. This weighted-sum approach leads to a single solution that represents one particular compromise in the objectives. Several other groups have also adopted this approach [67, 71 73]. 

The surfactant-free PLGA nanoparticles were prepared by a dialysis method using various solvents and their physiochemical properties were investigated with regard to the used solvent. Release kinetics of NFX showed that higher drug contents tend to larger particle sizes and slower release [25]. 

Both the type of drug delivery system and the specific type of delivery device can affect drug absorption via the nasal route. The choice of delivery system depends mainly on the physiochemical properties of the drug, its desired site of action, and, more importantly, patient compliance and marketing aspects. The formulations most commonly used in nasal delivery are solutions, suspensions, gels, dry powders, and, most recently, nanoparticulate formulations. 

In the TDS, the PSA as the formulation foundation loads many additives, including drugs and enhancers. Therefore the physiochemical properties of PSA... 

Sugawara M, Takekuma Y, Yamada H, Kobayashi M, Iseki K, Miyazaki K. A general approach for the prediction of the intestinal absorption of drugs Regress-sion analysis using the physiochemical properties and drug-membrane electrostatic interaction. J Pharm Sci 1998 87 960-6. 

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