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Physicochemistry and Basic ADME Properties for High Lipoidal Permeability Drugs

2 PHYSICOCHEMISTRY AND BASIC ADME PROPERTIES FOR HIGH LIPOIDAL PERMEABILITY DRUGS [Pg.56]

Drugs move across membranes by Transport versus passive diffusion [Pg.57]

TABLE 5.1 Physicochemistry and Lipid Permeability Classification of Drug Absorption, Bioavailability, Target Access, and Clearance [Pg.57]

Absorption Low (aliskiren) unless MWt less than Variable. Influenced by High via transceUular route [Pg.57]

Bioavailability As for absorption As for absorption and metabolism Variable. Influenced by metabolism [Pg.57]

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ADME

ADME properties

Drug ADME

Drug permeability

Drug properties

High Permeability

Lipoid

Permeability and

Permeability properties

Properties basicity