Physicochemical Properties of Naphthyridines

Data on the structures, physicochemical properties and reactivities of isomeric naphthyridines published up to 1984 inclusive, have been analyzed in sufficient detail in reviews (1970AHC123, 1983AHC95, 1983AHC147, 2000RCR201, 2001RCR299, 2004RCR637). 

X-ray diffraction analysis was also used to determine the structure of several 1,5-, 1,7-, 1,8- and 2,6-naphthyridine derivatives (1970AHC123, 1983AHC95, 1983AHC147, 1985CPB5551, 1987AX2198, 1988CJC2981, 1990AX2198, 

2-nitroso-1,3-diphenyl-1,2,3,4-tetrahydrobenzo[Z ][l,6]naphthyridine (2003AX(C)o 153), 5-amino-4-(4-dimethylaminophenyl)-2-(4-methoxyphenyl)-7-(pyrrolidin-l-yl)-l,6-nap-hthyridine-3-carbonitrile (2003AX(E)o200), 3,5-dichlorobenzo[A][l, 6]naphthyridine 

The UV spectral parameters of six isomeric formyl-substituted 4,6-benzo-l,5-and -1,6-naphthyridines were calculated (1998MI5). 

Spectroscopic techniques (UV, IR, H and 13C NMR) are widely used not only to identify naphthyridines but also to elucidate fine points concerning their structures (1970AHC123, 1983AHC147). 

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