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Physicochemical membrane permeability assay

Kansy, M., Senner, F., Gubemator, K. Physicochemical high throughput screening parallel artificial membrane permeability assay in the description of passive absorption processes. J. Med. Chem. 1998, 41, 1007-1010. [Pg.83]

Poor intestinal absorption of a potential drug molecule can be related to poor physicochemical properties and/or poor membrane permeation. Poor membrane permeation could be due to low paracellular or transcellular permeability or the net result of efflux from transporter proteins including MDRl (P-gp) or MRP proteins situated in the intestinal membrane. Cell lines with only one single efflux transporter are currently engineered for in vitro permeability assays to get suitable data for reliable QSAR models. In addition, efforts to gain deeper insight into P-gp and ABC on a structural basis are going on [131, 132]. [Pg.348]

See other pages where Physicochemical membrane permeability assay is mentioned: [Pg.349]    [Pg.349]    [Pg.28]    [Pg.22]    [Pg.116]    [Pg.411]    [Pg.469]    [Pg.75]    [Pg.211]    [Pg.121]    [Pg.179]    [Pg.116]    [Pg.383]    [Pg.351]    [Pg.458]   
See also in sourсe #XX -- [ Pg.349 ]



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