Phyltetralin synthesis

In certain cases, structure elucidation of aryltetralin lignans has only been established by total synthesis of the ( )-compounds. Noteworthy in this respect have been the constituents of Phyllanthus nlruri Linn. (Euphorbiaceae), extracts of which have been used medicinally (in treatment of asthma, jaundice and bronchial infections) (140). Considerable confusion resulted mainly from differing interpretations of spectroscopic data, and at least five different structures were proposed for the major constituent, hypophyllanthin. The structure of the aryltetralin constituents established by unequivocal synthesis (141) are shown in Scheme 30 they were given the names hypophyllanthin (1411. nirtetralin (1421. phyltetralin (1431 and lintetralin (1441. 

Ganeshpure P A, Schneiders G E, Stevenson R 1981 Structure and synthesis of hypophyllanthin, nirtetralin, phyltetralin and lintetralin. Tetrahedron Lett 22 393-396... 

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