Phyllomedusa bicolor

PhyUobatesspedes (poison frog)—177,397,416 Phyllomedusa bicolor (poison frog)-i77,397 Piaroa Indians of South America—168 picietl Nicotiana rustica)-% % yj picrotoxin—398... 

Negri L, Erspamer GF, Severinl C, et al. Dermorphin-related peptides from the skin of Phyllomedusa bicolor and their amidated analogues activate two p opioid receptor subtypes that modulate antinociceptlon and catalepsy In the rat. Proc Natl Acad Sci USA 1992 89 7203-7207. 

Phe-Ile-Gly-Leu-Met -NH2, a 10-peptide amide originally isolated from the skin of the South American frog Phyllomedusa bicolor. Phyllomedusin belongs to the tachykinins and shows similar pharmacological actions as physalaemin and uperolein [A. Anastasi, V. Erspamer, Experientia 1970, 26, 866]. 

Phylloxin (PLX-S), GWMSKIASGI GTF LSGVQQa, a 19-peptide amide from the skin secretion of the waxy monkey frog Phyllomedusa sauvagei. It is active against moUicutes (cell wall-less bacteria). PLX-S exhibits only a single site conservative amino acid substitution (Val for Met at position 17) when compared with phylloxin from P. bicolor. Phylloxin is a tmly novel prototype peptide of dermaseptins [T. N. Pierre etal., Eur.J. Biochem. 2000, 267,370 ... 

---