Hydrangea macrophylla phyllodulcin from

The dihydroisocoumarins phyllodulcin 39 and hydranginol 40 have been isolated from Hydrangea macrophylla leaves They have been synthesised as shown below... 

The dihydroisocoumarin, 3i -phyllodulcin (3, obtained from the leaves of Hydrangea macrophylla var. thunbergii via enzymatic hydrolysis), was mentioned earlier in the chapter as having commercial use. Recently, it has been demonstrated that this sweet substance occurs naturally in unprocessed leaves of its plant of origin as a 5 1 enantiomer with the previously undescribed compound, 3S -phyllodulcin [111]. Also reported in this study were the novel 3R- and SS-phyllodulcin 3 -O-glycosides, although the presence or absence of a sweet taste in these three new phyllodulcin analogs was not disclosed [111]. 

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