Phthalimides, conjugate addition

Diastereoselective tandem conjugate addition of both oxygen- and nitrogen-centred nucleophiles (potassium phthalimide, TsNHK, MeONa, and MesSiOK) to the novel (IN)-lO-camphorsulfonic acid-derived nitroalkenes (139 R = Me, Pr, and... 

Very recently, the conjugate addition of phthalimide salts to chiral a,/ -unsaturated imides has been reported. After further transformations, optically active /J-amino acid derivatives were obtainedl37. 

Addition to alkynoic esters. Conjugate addition of oximes to alkynoic esters to provide ( j-alkenyl oxime ethers is catalyzed by PhjP. Interestingly, a-addition by phthalimide is observed. Such adducts are useful precursors of dehydro-a-amino acids. ... 

Further investigations have been reported on the synthesis and the 0- and N-glycosidation of anomalously linked nucleosides of structure (3 ) formed by condensation of adenine derivatives or phthalimide with 2-deoxy-D-ribose presumably via an enal intermediate (c.f., Vol.20, p.95)- Benzyl and methyl acosaminide (35) has been obtained in 35 overall yield from L-rharanal dlacetate (36) by conjugate addition of hydrazoic acid to the masked enal (37) and mild glycosidation, followed by chromatographic separation from a 4 component mixture of the major a-L-arablno-isomer (Scheme 8). ... 

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