Phthalic acid monoamide

Primary and secondary amides and thioamides react with alkyl chlorofoimates with loss of CO2 or COS, forming iminium chlorides (82 equation 52). In some cases this method is complementary to the Pinner imido ester hydrochloride synthesis. The iminium salt (83 Scheme 6) formed by action of ethyl chloroformate on DMF is labile and decomposes rapidly to ethyl chloride. If the reaction is performed in the presence of NaBp4, the iminium salt (85) is isolable. Aryl chlorofoimates react in the same fashion with DMF or DMA, but in these cases the aryloxymethyleneiminium compounds are fairly stable, so this reaction is an important method for the preparation of compounds of this type. - Succinic acid monoamides, phthalic acid monoamides and related compounds are cyclized to iminium salts (86 equation 53) by treatment with acetic anhydride and HC104. ° With the aid of trifluoromethanesulfonic anhydride lactams and amides can be converted to dication ether salts (87) and (88 Scheme 7).22i.222... 

Phthalic acid monoamides from phthalic acid anhydrides... 

Another problem with air-exposed crystals of polar molecules is the formation of snrface hydrates and hydrolysis. PhthaUmide crystals have these possibilities, but the major (001) face protects the functional groups that are efficiently hidden under the hydrophobic benzene rings in bilayers. Only one of the two oxygen atoms is less efficiently shielded. So hydration appears possible, bnt hydrolysis to give phthalic acid monoamide shonld be impeded by the outermost molecular bilayer. Thus, only rare hydrolysis events around an initial snccessM penetration with island formation are expected. 

Parathion, Phorate Sulfur oxides, see Malathion Tartaric acid monoamide p-TCCH, see Lindane y-TCCH, see Lindane TCDD, see 2,4,5-Trichlorophenol Terbufos sulfone, see Terbufos Terbufos sulfoxide, see Terbufos Terephthalic acid, see p-Xylene o-Terphenyl, see Phthalic anhydride 2,2, 4,4 -Tetraamino-6,6 -azotoluene, see 2,4,6-Trinitrotoluene... 

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