Photoremovable protecting groups phenacyl

Zabadal, M., Pelliccioli, A.P., Klan, P. and Wirz, J. (2001) 2,5-Dimethyl-phenacyl esters A photoremovable protecting group for carboxylic acids. Journal of Physical Chemistry A, 105, 10329-10333. 

Case Study 6.24 Photoremovable protecting groups - 2,5-dimethyl-phenacyl chromophore... 

While not purported to be a photoremovable protecting group, the study by Anderson and Reese on substituted phenacyl chlorides did reveal an interesting photochemical rearrangement for certain members of the series, particularly the report that the Favorskii-like rearrangement ofp-hydroxyphenacyl chloride (27) in 1% aqueous ethanol gave two major photoproducts p-hydroxyacetophenone (28) and ethyl p-hydroxyphenyl acetate (29), as shown in Eq. (69.10). The authors proposed a spiro intermediate 30. 

A new method has been described for the protection of amino acids with a photoremovable group. This procedure involves the conversion of the amino acid into the phenacyl derivative (114). Irradiation of (114) in a buffered aqueous... 

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