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Photodynamic therapy excited porphyrin

Photodynamic therapy for the treatment of tumours involves the selective uptake and retention of a highly-coloured porphyrin sensitiser (Figure 6.17) in the tumour. Irradiation by a laser with a wavelength corresponding to the absorption maximum of the porphyrin (D) causes excitation of the porphyrin to the excited singlet state. [Pg.109]

In this chapter, we would like to introduce PIC micelles encapsulating ionic dendrimer porphyrins as a photosensitiser (PS) for photodynamic therapy (PDT). PDT is a topical therapeutic modality of malignant tumors, which treats tumor cells with cytotoxic singlet oxygen ( O2) produced by PS through photo-excitation at its characteristic wavelength A successful PDT may be completed by the development of potent PSs their tumor-selective delivery and selective and effective photoirradiation at the... [Pg.168]

The excited electrons in the triplet state from some dyes, for instance porphyrin, can sensitize the triplet ground state of oxygen into excited state singlet oxygen, which thus becomes toxic for cells. The reactive oxygen species (ROS) have been utihzed for the eradication of tumor cells, a process called photodynamic therapy (PDT). [Pg.19]


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See also in sourсe #XX -- [ Pg.231 ]




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