Photoactivatable substrates patterning

FIGURE 3.3.4 (a-e) Processes and (f-h) performances of cell patterning on the first-generation photoactivatable substrates. 

HGURE 3.3.15 Mechanism study of the third generation photoactivatable substrate impact of surface charge density and PEG backfilling, (a) Experimental design, (b) Ellipsometry. (c) Zeta potential, (d) BSA adsorption, (e) Long-term persistence of cellular patterns. 

Our group has developed for the first time photoactivatable dynamic substrates based on the photocleavage reaction of 2-nitrobenzyl ester (Fig. 3.3.2) [2] and have been made various technical and conceptual innovations. The common feature is that the surface is initially noncell adhesive, but changes to cell adhesive in response to near-UV irradiation. On these substrates, we are able not only to pattern cells in arbitrary geometries, but also to induce their migration by the secondary irradiation. One of the biggest advantages... 

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