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Photo-cross-linking reagent

Scheme 5 Structures of Some Hetero-bifunctional Photo-cross-linking Reagents and Their Incorporation into Peptides... Scheme 5 Structures of Some Hetero-bifunctional Photo-cross-linking Reagents and Their Incorporation into Peptides...
Alley, S.C., Ishmael, F.T., Jones, A.D., and Benkovic, S.J. (2000) Mapping protein-protein interactions in the bacteriophage T4 DNA polymerase holoenzyme using a novel trifunctional photo-cross-linking and affinity reagent./. Am. Chem. Soc. 122, 6126-6127. [Pg.1042]

Several applications of photoreactive peptides require the presence of a radionuclide to allow specific and sensitive detection of the photo-cross-linked conjugates. In several cases, radioiodination of tyrosyl moieties and radiolabeled Bolton-Hunter reagents have been used. However, the presence of a radiolabel within the benzophenone photophore is desirable, particularly when the objective is to identify the site of photo-insertion of benzophenone. To this end some radiolabeled, benzophenone-based compounds have been developed and used in peptide synthesis, in particular tritiated Phe(4-Bz) (Scheme 24)J2161 [1-14C-carboxy]-4-benzoylbenzoic acid,1221 and 4-benzoyl-(2,3-3H2)-dihydrocinnamic acid.[154l In addition, 4-(4-hydroxybenzoyl)phenylalanine (Scheme 25) has been directly radioiodinated with Na125I and Chloramine-T)151 ... [Pg.125]

See other pages where Photo-cross-linking reagent is mentioned: [Pg.389]    [Pg.392]    [Pg.389]    [Pg.392]    [Pg.39]    [Pg.88]    [Pg.89]    [Pg.114]    [Pg.183]    [Pg.184]    [Pg.322]    [Pg.302]    [Pg.206]    [Pg.163]    [Pg.164]    [Pg.42]    [Pg.3681]    [Pg.174]    [Pg.148]    [Pg.235]    [Pg.2591]    [Pg.193]    [Pg.234]    [Pg.309]    [Pg.219]    [Pg.214]    [Pg.216]    [Pg.288]    [Pg.129]    [Pg.86]    [Pg.262]   
See also in sourсe #XX -- [ Pg.389 , Pg.391 , Pg.392 , Pg.393 ]



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Cross-linking reagents

Linking reagents

Photo-cross-linking

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