Phosphorylcholine group

Kadoma, Y.. Nakabayashi, N., Masuhara, E. and Yamauchi, J. (1978) Synthesis and hemolysis test of the polymer containing phosphorylcholine groups. Kobunshi Ronbunshu, 35, 423-427. 

Watanabe J, Nederberg F, Atthoff B et al (2007) Cytocompatible biointerface on poly(lactic acid) by enrichment with phosphorylcholine groups for cell engineering. Mater Sci Eng 27 227-231... 

Figure 12. Schematic picture of suggested conformational changes of the phosphorylcholine group at the surface of the lecithin hilayers...

T. Konno, J. Watanabe, K. Ishihara, Conjugation of enzymes on polymer nanoparticles covered with phosphorylcholine groups. Biomacromolecules 5 (2) (2004) 342-347. 

The establishment of the fine synthetic route has encouraged further development of monomers bearing the phosphorylcholine group in the side chain, and a number of MPC derivatives have been synthesized (Figure 5.5). These often contain different polymerizable groups, a variety of spacer units between these groups, and a phosphorylcholine... 

Schema 6.6 Synthesis of some copolymers containing phosphorylcholine group.

Figure 11.9 Segmented polyurethane with phosphorylcholine group as side chain.

The MPC polymers suppressed protein adsorption well. It was reported that the theoretical amounts of BSA and BPF adsorbed on the surface in a monolayered state are 0.9 pg/cra and 1.7 pg/cm, respectively. On the surface of PMB30, the amount of adsorbed proteins was less than these theoretical values. Thus, the phosphorylcholine group is considered to reduce protein adsorption effectively. The effectiveness of the phosphorylcholine group, particularly the MPC unit, for reducing protein adsorption has been reported by other groups. ... 

---