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Phosphoribosyl aminoimidazole synthetase

Phosphoribosyl aminoimidazole synthetase Carbon-nitrogen Cyclization No Yes... [Pg.113]

Pho8phoribosyl-formyl-glycineamidine cyclo-ligase (ADP) Phosphoribosyl aminoimidazole synthetase... [Pg.120]

Phosphoribosyl aminoimidazole succinocarboxamide synthetase Carbon-nitrogen Aspartate amino transfer Yes Yes... [Pg.113]

The substrate specificity of adenylosuccinate synthetase is strict inosi-nate cannot be replaced by hypoxanthine, inosine, or phosphoribosyl aminoimidazole carboxamide L-aspartate cannot be replaced by ammonia or other d- or L-amino acids and other nucleoside mono-, di-, and triphosphates cannot replace GTP. Divalent cations are required. Bacterial, plant, and animal enzymes have similar specificities and general properties, although Michaelis constants differ somewhat. These are approximately 10 to 10 Af for GTP and aspartate, and 3 X Iff" M for ino-sinate. [Pg.143]

Fig. 15-16 The de novo purine biosynthetic pathway. Rib-5-P, ribose 5-phosphate P-Rib-PP, 5-phosphoribosyl 1-pyrophosphate PRA, 5-phosphoribosylamine IO-CHO-FH4, /Vl0-formyl tetrahydrofolate GAR, glycineamide ribotide FGAR. /V-formylglycineamide ribotide FGAM, /V-formylglycineamidine ribotide AIR, 5-aminoimidazole ribotide CAIR, 4-carboxy-5-aminoimidazole ribotide SAICAR, iV-succino-5-aminoimidazole-4-carboxamide ribotide AICAR, 5-aminoimidazole-4-carboxamide ribotide FAICAR, 5-formamidoimidazole-4-carboxamide ribotide sAMP, /V-succino-AMP. Enzymes (1) amido phosphoribosyltransferase (2) GAR synthetase (3) GAR transformylase (4) FGAM synthetase (5) AIR synthetase (6) AIR carboxylase (7) SAICAR synthetase (8) adenylosuecinase (9) AICAR transformylase (10) IMP cyclohydrolase (11) sAMP synthetase (12) adenylosuecinasc (13) IMP dehydrogenase (14) GMP synthetase. Fig. 15-16 The de novo purine biosynthetic pathway. Rib-5-P, ribose 5-phosphate P-Rib-PP, 5-phosphoribosyl 1-pyrophosphate PRA, 5-phosphoribosylamine IO-CHO-FH4, /Vl0-formyl tetrahydrofolate GAR, glycineamide ribotide FGAR. /V-formylglycineamide ribotide FGAM, /V-formylglycineamidine ribotide AIR, 5-aminoimidazole ribotide CAIR, 4-carboxy-5-aminoimidazole ribotide SAICAR, iV-succino-5-aminoimidazole-4-carboxamide ribotide AICAR, 5-aminoimidazole-4-carboxamide ribotide FAICAR, 5-formamidoimidazole-4-carboxamide ribotide sAMP, /V-succino-AMP. Enzymes (1) amido phosphoribosyltransferase (2) GAR synthetase (3) GAR transformylase (4) FGAM synthetase (5) AIR synthetase (6) AIR carboxylase (7) SAICAR synthetase (8) adenylosuecinase (9) AICAR transformylase (10) IMP cyclohydrolase (11) sAMP synthetase (12) adenylosuecinasc (13) IMP dehydrogenase (14) GMP synthetase.
Phosphoribosyl-1-pyrophosphate synthetase 2 aminophosphoribosyltransferase 3 phospho-ribosylglycinamide synthetase 4 glycinamide ribonucleotide transformylase 5 iV-formylglycin-amidine ribonucleotide amidoligase 6 5-aminoimidazole ribonucleotide synthetase 7 5-amino-imidazole ribonucleotide carboxylase 8 5-aminoimidazole-4-iV-succinocarboxamide ribonucleotide synthetase 9 adenylosuccinate lyase 10 5-aminoimidazole-4-carboxamide ribonucleotide transformylase 11 inosinicase... [Pg.308]

See other pages where Phosphoribosyl aminoimidazole synthetase is mentioned: [Pg.85]    [Pg.75]    [Pg.108]    [Pg.118]    [Pg.85]    [Pg.75]    [Pg.108]    [Pg.118]    [Pg.75]    [Pg.118]    [Pg.210]    [Pg.35]    [Pg.270]    [Pg.20]   
See also in sourсe #XX -- [ Pg.108 , Pg.120 ]



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