Phosphonoacetic acids antiviral activity

Phosphonoacetic acid antiviral activity, 6, 771 Phosphoprotein phosphatases activation... 

Herrin, T.R. and Fairgrieve, J.S., Triglyceride Ester of Phosphonoacetic Acid Having Antiviral Activity, U.S. Patent 4,150,125, 1979. 

Lambert, R.W., Martin, J.A., Thomas, G.J., Duncan, I.B., Hall, M.J., and Heimer. E.P., Synthesis and antiviral activity of phosphonoacetic and phosphonoformic acid esters of 5-bromo-2 -deoxyuridine and related pyrimidine nucleosides and acyclonucleosides, J. Med. Chem., 32. 367, 1989. 

Some aromatic thiosemicarbazones are active against smallpox virus, while phosphonoformic acid (PFA) and phosphonoacetic acid (PAA) are active against herpes viruses. Consequently, some acylphosphonate thiosemicarbazones, (47), in which the two types of structural moieties appear together, were synthesized and tested for antiviral activity. However, no inhibitory activity was observed against herpes and/or pox viruses . 

A substantial number of phosphonates have been prepared and tested against viral infections, including AIDS. Even relatively simple compounds such as the above-mentioned phosphonoformic acid (19, = 0) and phosphonoacetic acid (19, n= 1) were reported as antivirals and herpes virus inhibitors active against acyclovirresistant herpes and cytomegalovirus retinitis in patients with AIDS . The veterinary use has been mentioned ... 

---