Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Phospholipid amphipathic characteristic

It seems that for drugs to cause accumulation of phospholipids, the necessary physicochemical characteristic is the presence of both hydrophilic and lipophilic parts to the molecule, as exemplified by chlorphentermine (see chap. 3) (chap. 5, Fig. 1). They contain a hydrophobic ring structure and a hydrophilic side chain with a positively charged (cationic) amine group. Such molecules are known as cationic amphipathic drugs or CADs. Other drugs, all in use, known to cause phospholipidosis are amiodarone, chloroquine (chap. 5, Fig. 1), tafenoquine, and gentamycin. [Pg.225]

The general structural organization is similar for all the lipoprotein classes the apolipoproteins and amphipathic lipids (mostly phospholipids (PL) and unesterified cholesterol) form a 20-A-thick shell on the surface of spherical particles. This shell encloses the core of neutral lipids (triacylglycerols, cholesteryl esters (CE), and small amounts of unesterified cholesterol and other dissolved lipids, e.g., lipid-soluble vitamins). The main protein components are characteristic of each lipoprotein class they are indicated in Fig. 1, and will be described in detail in Section 3 of this chapter. [Pg.486]


See other pages where Phospholipid amphipathic characteristic is mentioned: [Pg.126]    [Pg.348]    [Pg.330]    [Pg.182]    [Pg.348]    [Pg.644]    [Pg.394]    [Pg.16]   
See also in sourсe #XX -- [ Pg.386 ]




SEARCH



Amphipathic

Amphipathicity

Amphipaths

© 2024 chempedia.info