Phospholidine 2-oxides

The X-ray crystal structural analysis of the optically active 2-chloro-l,3,2-diaza-phospholidine 2-oxide 97 has been reported. Reactions of 97 with chiral amino alcohols lead to ring opening and formation of the 1,3,2-... 

Enantioselective addition of diethylzinc to benzaldehyde has been promoted by indole-containing chiral oxazolidines (which are able to use both O and N atoms to effect metal coordination in the transition state), and by chiral o-hydroxyphenyl diaza-phospholidine oxide,and by chiral aziridino alcohols.Enantioselective addition of dialkylzinc to prostereogenic ketones has been promoted using chiral camphorsul-fonamide derivatives. 

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