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Phosphohydroxypyruvate, intermediate

Serine is synthesized from 3-phosphoglycerate, an intermediate in glycolysis. The first step is an oxidation to 3-phosphohydroxypyruvate. This a-ketoacid is transaminated to 3-phosphoserine, which is then hydrolyzed to serine. [Pg.997]

Phosphoglycerate dehydrogenase catalyzes the conversion of 3-phosphoglycerate to 3-phosphohydroxypyruvate, an intermediate in the biosynthesis of serine. [Pg.1027]

One advantage of this pathway over serine dehydratase is that in transamination free ammonia is not released and the potential difficulty of ammonia toxicity is minimized. Serine in people is not an essential amino acid and can be synthesized in the liver from the glycolytic intermediate 3-phosphoglycerate, which can be oxidized to phosphohydroxypyruvate and then transaminated with glutamate to form phosphoserine. The... [Pg.489]

See other pages where Phosphohydroxypyruvate, intermediate is mentioned: [Pg.435]    [Pg.435]    [Pg.349]    [Pg.337]    [Pg.361]    [Pg.459]    [Pg.625]    [Pg.215]   


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3- Phosphohydroxypyruvate

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