3-Phosphoglycerate kinase reaction catalyzed

This reaction is catalyzed by phosphoglycerate kinase and is reversible. 

Notice that phosphoglycerate kinase is named for the reverse reaction. Like all enzymes, it catalyzes the reaction in both directions. This enzyme acts in the direction suggested by its name during gluconeogenesis (see Fig. 14-16) and during photosynthetic C02 assimilation (see Fig. 20-4). 

Thus, the outcomes of the reactions catalyzed by glyceraldehyde 3-phosphate dehydrogenase and phosphoglycerate kinase are ... 

Like all anhydrides, the mixed carboxylic-phosphoric anhydride is a reactive substrate in nucleophilic acyl substitution reactions (Section 21.5). Reaction of 3-phosphoglyceroyl phosphate with ADP occurs with nucleO philic attack on phosphorus and results in transfer of a phosphate group to yield ATP and 3-phosphoglycerate. The process is catalyzed lay the enzyme j phosphoglycerate kinase. Note that the carboxylic acid group is written in its, dissociated form to reflect the state in which it exists at physiological pH. I... 

One type of evidence often presented in support of double-displacement mechanisms involving covalent enzyme-substrate intermediates is the observation of exchange reactions of the type discussed above for galactose-1-P uridylyltrans-ferase and acetate kinase. The exchange reactions (19a) and (19b), where PGA is 3-phosphoglycerate and DPG is 1,3-diphosphoglycerate, are catalyzed by phosphoglycerate kinase (68, 70). 

The acyl-phosphate group at position 1 is much more energy rich than the phosphate anhydride of ATP, so 1,3BPG has the energy to drive synthesis of ATP from ADP + Pi, which it does in the glycolysis reaction catalyzed by the enzyme phosphoglycerate kinase. 

This reaction is one of two substrate level phosphorylations in glycolysis (the other is catalyzed by phosphoglycerate kinase). The enzyme is a key control point for glycolysis. 

The reaction catalyzed by the enzyme phosphoglycerate kinase. In this reaction, a high energy phosphate from 1,3 bisphosphoglycerate is transferred to ADP to form ATP and 3-phosphoglycerate. 

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