Phosphoenolpyruvate synthetase regulation

Studies on the regulation of the common pathway of aromatic biosynthesis in several micro-organisms have shown that control of the first reaction (Figure 1.2), the conversion of o-erythrose-4-phosphate (7) and phosphoenolpyruvate (8) to 3-deoxy-o-arabino-heptulosonic acid-7-phosphate (9, DAHP), catalysed by the enzyme DAHP synthetase (EC 4.1.2.15) is an important factor in the overall control of the pathway In a number of enteric bacteria this enzyme exists in multiple molecular forms each of which is under the feedback control of a specific end-product. Thus in Escherichia coli there are three DAHP synthetases (iso-enzymes), the activity and formation of which are controlled by the three aromatic amino acids The formation and activity of DAHP synthetase... 

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