Phosphinic diacids

Fig. 3. Synthesis of diacidic and monoacidic N-1 a2etidinone phosphonates and phosphinates where TMSBr is trimethylsilyl bromide BSA is...

TiR, Ti(OR)4 or condensed derivatives Compounds with phosphinic acid Various diols Various alcohols and acids Various alcohols and acids Various diacids 42,65,69) 16,47-50, 53,54,71, 74,75,77, 117, 187-189, 221-227, 230,232) 331)... 

S Mantha, et al. Development of an enzyme immunoassay (EIA) for SQ27, 519, the active phosphinic-carboxylic diacid of the prodrug fosinopril, in human serum— A comparison with the SQ27, 519 RIA, Clin Chem 34 1153, 1988. 

Finally, Nasopoulou et al. presented a method to discriminate the two acidic groups of Fmoc diacids 25 by using the phenacyl (Pac) group, which can be selectively removed from the phosphinic moiety upon heating with TFA (Scheme 14) [89]. After Ad-protection, Pac carboxylic ester can be easily cleaved by metal reduction, furnishing the target molecules 29 in moderate overall yields. 

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