Phosphatide deuterium

Ability of the adrenalectomized animal to synthesize new phosphatide molecules was established. The rate of formation of labeled phosphatide molecules in liver and small intestine of the rat is not influenced by complete removal of both adrenal glands (32,170a). Nor is the rate of incorporation of deuterium-containing fatty... 

In connection with the above consideration, it is of interest to consider some results obtained by Cavanagh and Raper (31). They found that the glycerides extracted from the plasma of rats six hours after feeding of deuterium-containing linseed oil contained ten times as much deuterium (in atoms per cent) as the phosphatides of the plasma. This result is understandable if most of the phosphatide molecules present in the plasma have been synthesized in the liver and not taken up from the intestine. 

Deuterium Content op Phosphatide Fractions after Feeding Fat Containing 4-6 Atom Per Cent Deuterium (31)... 

At all intervals the highest values for deuterium content were observed in liver phosphatides. The smallest incorporation of deuterium was observed in brain phosphatides, and thus the result obtained was similar to results of the incorporation of into phosphatides of different organs. The observation that plasma phosphatides have lower deuterium values than liver at the end of six hours was interpreted as suggesting incorporation of deuterated fatty acids into liver phosphatide. A similar conclusion was drawn concerning incorporation of phosphate into the phosphatide molecule (see page 156). 

After keeping mice on a stock diet containing 20% deuterated linseed oil for three days, the liver phosphatide fatty acids were found, by Barrett and his associates (21), to contain nearly three times as much deuterium as body phosphatides. 

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