Phosphatases binding site comparison

The crystal structure of recombinant bovine inositol polyphosphate 1-phosphatase (1-ptase) was determined in the presence of Mg + at 2.3-A resolution (York et al., 1994). The fold of 1-ptase is similar to that of two other metaI-dependent/Li+-sensitive phosphatases, inositol monophosphate phosphatase and fructose 1,6-biphosphatase. Comparison of the active-site pockets of these proteins will likely provide insight into substrate binding, the mechanisms of metal-dependent catalysis, and Li+ inhibition. 

---