Phenytoin hirsutism with

Choice of drug is also determined by the patient s age and sex. This is particularly true for women who prefer to avoid drugs associated with teratogenesis or that have adverse effects on their appearance, e.g. hirsutism from phenytoin. 

Common adverse effects of phenytoin include nystagmus, diplopia, and ataxia. With chronic use, abnormalities of vitamin D metabolism and coarsening of facial features may occur. Gingival overgrowth and hirsutism also occur to some degree in most patients. The answer is (D). 

Co-cyprindiol is a mixture of the anti-androgenic progestogen, cyproter-one acetate 2 mg, with ethinylestradiol 35 micrograms. It is used for the treatment of acne and moderately severe hirsutism in women who may also wish to use it as an oral contraceptive, and its contraceptive efficacy is expected to be reduced by the same hepatic enzyme inducers (see Table 28. r, (p.975)) that interact with conventional combined oral contraceptives. The precautions described in this section for the combined hormonal contraceptives with the various drugs listed in Table 28.1 , (p.975), should therefore be followed, see Hormonal contraceptives + Antiepileptics Barbiturates or Phenytoin , p.985. 

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