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3- Phenylpyrazine 1-oxide

Phenyl-2-pyrazinecarboxylic acid 5-Phenyl-2,3-pyrazinediamine 5-Phenyl-2,3-pyrazinedicarbonitrile 5-Phenyl-2,3-pyrazinedicarboximide 5-Phenyl-2,3-pyrazinedicarboxylic acid 5- Phenyl-2,3(1 H, 4//)-pyrazinedione 2-Phenylpyrazine 1,4-dioxide 2-Phenylpyrazine 1-oxide... [Pg.453]

The dipole moment of pyrazine 1-oxide has been determined in benzene at 25° as 1.66D, and comparison with those obtained by SMO (simple molecular orbitals) calculations show that agreement is good (748). Other determinations of dipole moment were as follows pyrazine 1-oxide, 1.60 (carbon tetrachloride, 25°) (749) and 1.62 (benzene, 25°) (663) 2,5- and 3,5-dimethylpyrazine 1-oxides, 1.68 and 2.14, respectively (benzene, 25°) (663) 2-phenylpyrazine 1-oxide, 1.39 (benzene, 25°) (733a) and 3-phenylpyrazine 1-oxide, 2.03 (benzene, 25°) (733a). [Pg.88]

Alkoxypyrazine A-oxides may also be prepared by oxidation of the alkoxypyrazine with peroxyacetic acid. In this way the following have been prepared 3-ethoxypyrazine 1-oxide (100°/20h) (978) 3-(trideuteromethoxy)pyrazine 1-oxide (757l9h) (975) 3-ethoxy-2-methylpyrazine 1-oxide (65-75724h) (978) 3-methoxy-2-phenylpyrazine 1-oxide (55720 h) (817) 3-ethoxy-2,5-dimethyl-pyrazine 1-oxide (56716 h) (872) 3-carbamoyl-2-methoxypyrazine 1-oxide (80720h) (881) and 2-cyano-5-ethoxy-3,6-dimethylpyrazine A-oxide (55720h) (288). [Pg.189]

Alkoxy groups again direct attack to the more remote nitrogen site, probably for steric reasons. Thus, 2-ethoxypyrazine gave 45% and 2-methoxy-3-methylpyrazine 82% of the 4-oxides (64JOC2623). Isolation of an almost quantitative yield of 4-oxide from 2-methoxy-3-phenylpyrazine oxidation... [Pg.157]

The reductive decyanation of cyanopyrazine using H2 and Pt/C under acidic conditions has been reported <2002TL6747>, that is, 2-amino-3-cyano-5-phenylpyrazine 1-oxide 73 is hydrogenated to 2-amino-5-phenylpyra-zine 74 in 90% yield (Equation 11). The double reduction has also been shown to be realized with sodium dithionite. [Pg.292]

Another key intermediate for pteridine synthesis was also seen in 2-amino-3-ethoxycarbonyl-5-phenylpyrazine 1-oxide which reacts with various amines to form the corresponding amides followed by cyclization with triethyl orthoformate giving 3-alkyl-6-phenyl-4(3/7)pteridinone 8-oxides <87JHC1109>. The synthesis of 2,4-diamino-6-methylpteridine 5-oxide (371) was achieved from 5-methyl-pyrazine-2-carboxamide (366) via the 4-oxide (367), a Hofmann degradation (368), bro-mination (369), and cyanation (370) followed by cyclization with guanidine to give (371) (Scheme 60) <93JHC841>. [Pg.720]

Chloro-3-methyl-5-phenylpyrazine 1-oxide (44) gave 2,6-dichloro-3-methyl-5-phenylpyrazine (45) (POCl3, 80°C, 30 min 93%) analogues likewise.57... [Pg.145]

Phenylpyrazine 4-oxide (52) gave a separable mixture of 2-chloro-... [Pg.146]

Chloro-3-isobutylpyrazine 4-oxide gave 3-isobutyl-2( I // )-pyrazinone 4-oxide (111, R = Hu ) (5 M NaOH, reflux, 2 h 39%) 86 2-chloro-3-phenylpyrazine 4-oxide gave 3-phenyl-2( I //(-pyrazinone 4-oxide (111, R = Ph) (KOH, H20—EtOH, reflux, 1 h 30%) 1290 also analogues likewise.1290... [Pg.158]

Chloro-6-phenylpyrazine 4-oxide (129, R = Cl) gave 2-methoxy-6-phenylpyrazine 4-oxide (129, R = OMe) (MeONa, MeOH, reflux, 20 h ... [Pg.162]

Phenylpyrazine 4-oxide (268) gave a separable mixture of 2-acetoxy-6-phenylpyrazine (269), 2-acetoxy-3-phenylpyrazine (270), and 2-acetoxy-5-phenylpyrazine (271) [Ac20, Et3N, reflux, A, 6 h 68, 11, 8% respectively (by NMR), isolated in much lower yields].1575... [Pg.234]

Phenylpyrazine 4-oxide gave a mixture of 2-p-methoxybenzylthio-3-phenylpyrazine (296, R = SCH2C6H4OMe-p), its 5-phenyl isomer, and its 6-phenyl isomer [HSCH2C6H4OMe-p, Et2NCOCl, MeCN, reflux, 6 h 63, 43, 0% (isolated) or likewise with the addition of ZnBr2 21, 38, 41% (estimated by NMR)] 43 also other examples, all with the same thiol.43... [Pg.238]

Hydrazino-6-methyl-3-phenylpyrazine 4-oxide gave 2-methyl-5-phenyl-pyrazine 4-oxide (CuS04, AcOH—H20, 95°C, 1 h >42%).80... [Pg.294]

Acetoxymethyl-6-methylpyrazine 2-Acetoxymethyl-5-methylpyrazine 1,4-dioxide 2-Acetoxymethyl-5-methylpyrazine 1-oxide 2-Acetoxymethyl-5-methylpyrazine 4-oxide 2- Acetoxymethyl-5-phenylpyrazine 2-Acetoxymethyl-6-phenylpyrazine... [Pg.353]

Chloro-3-isobutyl-6-methylpyrazine 1-oxide 2-Chloro-6-isobutyl-3-methylpyrazine 1-oxide 2-Chloro-6-isobutyl-3-methylpyrazine 4-oxide 2-Chloro-3-isobutyl-5-phenylpyrazine 2-Chloro-3-isobutylpyrazine... [Pg.390]

Chloro-3-methyl-5-phenylpyrazine 4-oxide 2-Chloro-3-methyl-6-phenylpyrazine 4-oxide 2-Chloro-5-methyl-3-phenylpyrazine 1-oxide 2-Chloro-5-methyl-3-phenylpyrazine 4-oxide 2-Chloro-5-methyl-6-phenylpyrazine 4-oxide 2-Chloro-6-methyl-3-phenylpyrazine 1-oxide 2-Chloro-6-methyl-3-phenylpyrazine 4-oxide... [Pg.392]

Dimethylamino-7V-hydroxy-2-pyrazinecarboxamide 6-Dimethylamino-7V-hydroxy-2-pyrazinecarboxamidine 2-Dimethylamino-5-iodopyrazine 2-Dimethylamino-6-iodopyrazine 2-Dimethylamino-5-iodopyrazine 4-oxide 2-Dimethylamino-3-isobutylpyrazine 2-Dimethylamino-6-isobutylpyrazine 2-Dimethylamino-5-methoxy-3,6-dimethylpyrazine 2-Dimethylaminomethyl-3,6-bismethylthiopyrazine 2-Dimethylamino-6-methyl-5-phenylpyrazine 4-oxide 2-Dimethylamino-3-methylpyrazine 2-Dimethylamino-6-methylpyrazine 2-Dimethylamino-3-methylpyrazine 4-oxide Dimethyl 5-amino-6-oxo-1,6-dihydro-2,3-pyrazinedicarboxylate 2-Dimethylamino-5-phenylpyrazine 2-(3-Dimethylaminopropyl)-6-methylpyrazine... [Pg.410]

Ethylthio-2-pyrazinecarbonitrile 6-Ethylthio-2-pyrazinecarbonitrile 6-Ethylthio-2-pyrazinecarbothioamide 3-Ethylthio-2-pyrazinecarboxamide 6-Ethylthio-2-pyrazinecarboxamide 3-Ethylthio-2-pyrazinecarboxylic acid 6-Ethylthio-2-pyrazinecarboxylic acid 3-Ethylthio-2,5-pyrazinedicarboxamide 2-Ethylthiopyrazine 1-oxide 2-Ethyl-3,5,6-trimethylpyrazine 2-Ethyl-3,5,6-triphenylpyrazine 2-Ethyl-3-vinylpyrazine 2-Ethynyl-3,6-dimethylpyrazine 2-Ethynyl-3-methylpyrazine 2-Fluoro-5,6-dimethoxy-3-methylpyrazine 2- Fluoro- 5,6-dimethoxypyrazine 2-Fluoro-3,6-dimethylpyrazine 2-Fluoro-3-(l-hydroxyethyl)pyrazine 2-Fluoro-3-iodopyrazine 2-Fluoromethyl-5-methyl-3,6-diphenylpyrazine 2- Fluoro- 5-phenylpyrazine 2-Fluoro-3-phenylthiopyrazine... [Pg.423]

Methoxy-6-phenyl-2-pyrazinecarbonitrile 2-Methoxy-3-phenylpyrazine 4-oxide 2-Methoxy-5-phenylpyrazine 4-oxide... [Pg.437]

Methyl-3-phenyl-2-pyrazinamine 1-oxide 2- Methyl-3 -phenylpyrazine... [Pg.447]

Propyl-2-pyrazinecarboxylic add 2-Propylpyrazine 1,4-dioxide 2-Propylpyrazine 1-oxide 2-Phenylpyrazine 4-oxide... [Pg.454]

See other pages where 3- Phenylpyrazine 1-oxide is mentioned: [Pg.153]    [Pg.453]    [Pg.275]    [Pg.303]    [Pg.316]    [Pg.156]    [Pg.158]    [Pg.158]    [Pg.158]    [Pg.25]    [Pg.148]    [Pg.352]    [Pg.354]    [Pg.392]    [Pg.392]    [Pg.393]    [Pg.403]    [Pg.403]    [Pg.405]    [Pg.405]    [Pg.407]    [Pg.407]    [Pg.408]    [Pg.408]    [Pg.413]    [Pg.413]    [Pg.436]    [Pg.436]    [Pg.437]    [Pg.448]    [Pg.448]    [Pg.453]   
See also in sourсe #XX -- [ Pg.153 ]



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2- Methoxy-6-phenylpyrazine 4-oxide

2-Chloro-3-phenylpyrazine 4-oxide

2-Phenylpyrazine

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