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2- Chloro-6-phenylpyrazine 4-oxide

Chloro-3-isobutylpyrazine 4-oxide gave 3-isobutyl-2( I // )-pyrazinone 4-oxide (111, R = Hu ) (5 M NaOH, reflux, 2 h 39%) 86 2-chloro-3-phenylpyrazine 4-oxide gave 3-phenyl-2( I //(-pyrazinone 4-oxide (111, R = Ph) (KOH, H20—EtOH, reflux, 1 h 30%) 1290 also analogues likewise.1290... [Pg.158]

Chloro-6-phenylpyrazine 2-Chloro-3-phenylpyrazine 1,4-dioxide 2-Chloro-5-phenylpyrazine 1,4-dioxide 2-Chloro-3-phenylpyrazine 1-oxide 2-Chloro-3-phenylpyrazine 4-oxide 2-Chloro-5-phenylpyrazine 1-oxide 2-Chloro-5-phenylpyrazine 4-oxide 2-Chloro-6-phenylpyrazine 1-oxide... [Pg.393]

Chloro-3-methyl-5-phenylpyrazine 1-oxide (44) gave 2,6-dichloro-3-methyl-5-phenylpyrazine (45) (POCl3, 80°C, 30 min 93%) analogues likewise.57... [Pg.145]

Phenylpyrazine 4-oxide (52) gave a separable mixture of 2-chloro-... [Pg.146]

Chloro-6-phenylpyrazine 4-oxide (129, R = Cl) gave 2-methoxy-6-phenylpyrazine 4-oxide (129, R = OMe) (MeONa, MeOH, reflux, 20 h ... [Pg.162]

Chloro-3-isobutyl-6-methylpyrazine 1-oxide 2-Chloro-6-isobutyl-3-methylpyrazine 1-oxide 2-Chloro-6-isobutyl-3-methylpyrazine 4-oxide 2-Chloro-3-isobutyl-5-phenylpyrazine 2-Chloro-3-isobutylpyrazine... [Pg.390]

The following alkoxypyrazines have been prepared from the corresponding dichloropyrazines and alkoxide ions 2,3-dimethoxy-5,6-dimethyl(and diphenyl) (797) 2,3-dibenzyloxy (sodium benzyl oxide in benzyl alcohol at reflux for 24 hours (883)] [but 23-dichloropyrazine with sodium hydride and benzyl alcohol in xylene gave l,4-dibenzyl-2,3-dioxo-l,2,3,4-tetrahydropyrazine)(988)] 2-chloro-5-methoxy (838) 2,5-diethoxy-3,6-dimethyl (872) 2methanolic sodium methoxide refluxed for 2 h) 2,5-dimethoxy-3-phenyl (817) 2-chloro-5-methoxy(and ethoxy)-3,6-diphenyl (817) 2,5-dimethoxy-3,6-dimethyl (and diisopropyl) (844) 2,5-dimethoxy-3-isopropyl-6-methyl (methanolic potassium methoxide at reflux for 6 days) (844) 2(5)-s-butyl-3-chloro-6-ethoxy-5(2)-isobutyl (93) 2-chloro-6-methoxy (838, 883) 2,6-dimethoxy (reflux for 8h) (832) 2,6-diethoxy (reflux for 14 h) (883) 2-benzyloxy-6-chloro (1 equiv. of sodium hydride and benzyl alcohol in benzene at reflux) (832) 2,6-dibenzyloxy (5 equiv. of sodium benzyloxide in benzene at reflux gave 70%) (832) and 3,5-dimethoxy-2-methyl (535). [Pg.136]

Chloro-5-phenylpyrazine l(and 4)-oxides have been deoxygenated in good yield with aqueous chromium(Il) chloride in methanol and acetone at room temperature (761). [Pg.153]

Chloropyrazine 1-oxide with phenylmagnesium bromide in tetrahydrofuran at reflux gave 2-chloro-6-phenylpyrazine 1-oxide (733b). [Pg.153]

Phenylpyrazine 4-oxide (52) gave a separable mixture of 2-chloro-3-phenylpyrazine (53), 2-chloro-5-phenylpyrazinc (54), and 2-chloro-... [Pg.146]

Chloro-3-isobutylpyrazine 4-oxide gave 3-isobutyl-2(l//)-pyrazinone 4-oxide (111, R = Bu ) (5 M NaOH, reflux, 2 h 39%) 2-chloro-3-phenylpyrazine... [Pg.158]

See other pages where 2- Chloro-6-phenylpyrazine 4-oxide is mentioned: [Pg.393]    [Pg.619]    [Pg.275]    [Pg.316]    [Pg.158]    [Pg.354]    [Pg.392]    [Pg.392]    [Pg.393]    [Pg.153]    [Pg.166]    [Pg.392]    [Pg.392]    [Pg.392]    [Pg.392]    [Pg.392]    [Pg.392]    [Pg.392]    [Pg.392]    [Pg.392]    [Pg.393]    [Pg.393]    [Pg.393]    [Pg.393]    [Pg.393]    [Pg.393]   


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2- Phenylpyrazine 1-oxide

2-Phenylpyrazine

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