1-Phenylcyclopentanecarboxylic acid

Chemical Name 1-Phenylcyclopentanecarboxylic acid 2-(diethylamino)-ethyl ester 1,2-ethanedisulfonate... 

CN 1-phenylcyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester... 

Phenylcyclopentanecarboxylic acid, with ethyl chlorocar-bonate to give mixed carboxylic-carbonic anhydride, 51, 48... 

In addition to the present method, 1-phenylcyclopentane-carboxaldehyde has been prepared by the reduction of N-acylaziridines obtained from 1-phenylcyclopentanecarboxylic acid.9... 

Phenylcyclopentanecarboxylic acid,2,3 m.p. 157-159°, was obtained from Aldrich Chemical Company, Inc. 

Phenylcyclopentylamine has also been prepared from 1-phenylcyclopentanecarboxylic acid by means of the Hofmann degradation of the intermediate amide4 6 and from the intermediate carboxylic acid chloride by the Curtius reaction.6 In the method described, using the mixed carboxylic-carbonic anhydride,7 improved yields of the amine are obtained. 

SynonyHai 1-Phenylcyclopentanecarboxylic acid 2-(2-diethylaminoethoxy)ethyl-ester pentoxyverine, pentoxlverln Trade aueat... 

When the carboxyl group is attached to a ring, the name of the compound must be modified the same way as is done with aldehydes. Compound 43, for example, is named 1-methylcyclooctanecarboxylic acid. Similarly, 44 is 1-methyl-2-phenylcyclopentanecarboxylic acid. 

Diethyl ethylthioethyl phosphorothioate, 512 Diethyl isopropylmethylpyrimidinyl phosphorothioate, 528 Diethyl nitrophenyl phosphorothioate, 853 Diethyl oxide, 595 Diethyl phthalate, 538 Diethylamide nicotinic acid, 813 Diethylamine, 567 Diethylaminoacetoxylidide, 705 Diethylaminoethanol, 452, 805, 925 Diethylaminoethoxydimethylaminobenzothiazole, 525 Diethylaminoethoxyethyl ethylphenylbutyrate, 837 Diethylaminoethoxyethyl phenylcyclopentanecarboxylate, 431 Diethylaminoethyl aminobenzoate, 925 Diethylaminoethyl aminobutoxybenzoate, 840 Diethylaminoethyl aminochlorobenzoate, 451 Diethylaminoethyl 3-amino-4-propoxybenzoate, 943 Diethylaminoethyl 4-amino-2- propoxybenzoate, 936 Diethylaminoethyl benzilate, 375 Diethylaminoethyl bicyclohexylcarboxylate, 535 Diethylaminoethyl diphenylacetate, 320... 

Whereas palladium(0)-catalyzed reactions of dialkyl fumarate and dialkyl maleate yield reaction products identical to those obtained from the phosphane-modified nickel-catalyzed reactions (vide supra), analogous palladium(0)-catalyzed reactions with ( )-but-2-enoic or (E)-cinnamic acid derivatives lead to different products to the nickel-catalyzed reactions, i.e. in the palladium-catalyzed reactions formal distal cleavage of but-2-enoic MCP occurs to provide methyl tra i-2-methyl-4-methylenecyclopentanecarboxylate (12, R = Me) and methyl trans-4-methylene-2-phenylcyclopentanecarboxylate (12, R = Ph), respectively." Yields and stereoselectivities are slightly higher with palladium(O) catalysts. When R = Me, 7.4% of the C-C double bond isomerization product, methyl traM -2,4-dimethylcyclopent-3-enecarboxylate (13, R = Me), is additionally obtained, raising the combined yield of cyclocodimers to 49.9%. With methyl (jE )-cinnamate, analogous isomerization only occurs upon workup, i.e. distillation of the crude product. 

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