Phenylative Radical Cyclization with Phenyl Grignard Reagent

Cobalt-catalyzed Phenylative Radical Cyclization with Phenyl Grignard Reagent 

Halo acetals bearing a terminal alkene moiety underwent phenylative cyclization to give the corresponding benzyl-substituted tetrahydrofuran derivative in good to 

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Cobalt-catalyzed coupling of halo acetal with a phenyl Grignard reagent proceeded smoothly, and involved radical cyclization before coupling. A variety of substrates were examined the results obtained are shown in Tab. 3.25 and Scheme 3.156 [171]. 

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