2-phenyl-propiophenone hydrogenation

S,S)-[Ru] frans-[RuCl2((S)-xylBINAP)((S)-DAIPEN)] Scheme 2.20 Hydrogenation of 2-phenyl-propiophenone. 

Phenylpropanolamine Phenylpropanolamine, D,L-erythro-1 -phenyl-2-methylamino-propanol-1 (11.3.7), is synthesized from propiophenone by nitrosation into an isonitroso derivative (11.3.6). Reduction of this by hydrogen in hydrochloric acid while simultaneously using two catalysts, palladium on carbon and platinum on carbon, gives norephedrine (11.3.7) [56-59]. 

If you run the NMR spectrum of a simple carbonyl compound (for example, 1-phenyl-propan-1-one, propiophenone ) in D2O, the signal for protons next to the carbonyl group very slowly disappears. If the compound is isolated from the solution afterwards, the mass spectrum shows that those hydrogen atoms have been replaced by deuterium atoms there is a peak at (M + 1)+ or (M + 2)+ instead of at AT1-. To start with, the same keto-enol equilibrium is set up. 

Given in Table 8 are the deuterium/hydrogen isotope effects observed during formation of the derivatives of trideuterioacetophenone, hexa-deuterio-f-butyl phenyl ketone, and two isotope position isomers of deuterated propiophenone, all determined by the experimental method just discussed. 

Propiophenone. See Ethyl phenyl ketone Propiophenone, 2-hydroxy-2-methyl-. See 2-Hydroxy 2-methyl 1-phenyl 1-propanone Propomeen 2HT-11. See Bis hydrogenated tallowalkyl-2-hydroxypropyl amine Propomeen C/12. See PPG-2 cocam I ne Propomeen HT/12. See PPG-2 hydrogenated tallowamine... 

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