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6-Phenyl-2-phenyloxazolo 4,5-/? pyridine

Attempts to make oxazolylboronic acids failed probably due to the equilibrium between cyclic and acyclic valence bond tautomers of the lithiooxazoles. A somewhat relevant Suzuki coupling involved the Pd-catalyzed cross-coupling of 6-bromo-2-phenyloxazolo[4,5-6]pyridine with phenylboronic acid to provide 6-phenyl-2-phenyloxazolo[4,5-6]pyridine [15]. [Pg.326]

Phenyloxazolo[4,5-6]pyridine (294) and 2-phenyloxazolo[5,4-6]pyridine substituted in the phenyl ring have good antiinflammatory and analgesic activity. Some compounds possess activity comparable to phenylbutazone or indomethacin without producing the irritation in the gastrointestinal tract that acidic antiinflammatory compounds cause (78JMC1158). [Pg.668]


See also in sourсe #XX -- [ Pg.389 ]




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