4-Phenyl-2-butanone, electroenzymatic reduction

Figure 22.4 Electroenzymatic reduction of 4-phenyl-2-butanone catalyzed by HLADH with in situ indirect electrochemical regeneration of NADH.

This system has been successfully applied to the in-situ electroenzymatic reduction of pyruvate to D-lactate using the NADH-dependent D-lactate dehydrogenase or the reduction of 4-phenyl-2-butanone to (5)-4-phenyl-2-butanol using the NADH-dependent horse liver alcohol dehydrogenase (HLADH) with high enantioselectivity (Fig. 22.4) [65]. 

A common class of mediators, which fulfill these requirements, are rhodium complexes (e.g., tris(2,2 -bipyridyl)- and substituted or nonsubstituted (2,2 -bipyridyl) (pentamethylcy-clopentadienyl)-rhodium complexes). This regeneration system has been efficiently applied in electroenzymatic reduction of pyruvate to D-lactate and the reduction of 4-phenyl-2-butanone to (S)-4-phenyl-2-butanol [1]. In an electrochemical membrane reactor, NADH was... 

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See also in sourсe #XX -- [ ]

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