1- Phenyl-2-bromopropane

BROM-O-GAS , methyl bromide, 27 4-Bromophenyl phenyl ether, 27 Bromopropane, 28... 

Preparation 325.—jS-Phenyl-jS-Bromopropionic Acid [Z-Phenyl-Z-bromopropan add. ... 

Dibromo-l-methoxypropane in turn with phenylmagnesium-bromide gave the product, which after hydrolysis yielded l-phenyl-l-methoxy-2-bromopropane. 

To the solution of l-phenyl-l-methoxy-2-bromopropane methylamine was added and as a result of the reaction l-phenyl-l-methoxy-2-methylaminopropane was obtained. After that l-phenyl-l-methoxy-2-methylaminopropane on hydrolysis with hydrobromic acid yielded 1-phenyl-l-hydroxy-2-methylaminopropane, i.e. racemic pseudoephedrine. The racemic base was resolved, by crystallization of their tartrates, into I- and d-pseudoephedrine. The base l-pseudoephedrine forms white rhombic crystals, melting point 118°C. The salt pseudoephedrine sulfate may be prepeared by... 

Oxidation of the ethylene acetals of 3-aryl-3-oxo-2-propyl phenyl telluriums, which were prepared from the acetals of 3-aryl-3-oxo-2-bromopropane and arenetellurolates, with 3-chloroperoxybenzoic acid in methanol at 20° produced hydroxyethyl 2-arylpropanoates2. Tellurones were postulated as intermediates that experienced a 1,2-aryl shift and the elimination of an aryltelluro moiety. 

A mixture of 5.0 g dibenzenesulfonyl derivative (10 mmol), 30 mL 48% HBr, and 200 mL ethanol was refluxed for 3 h. The cooled reaction mixture, containing 3-phenyl-2-benzenesulfonamido-1 -bromopropane was neutralized with 5% NaOH diluted with 300 mL cold water, and then treated with 185 mL 5% NaOH. After the alkaline mixture was stirred for 15 min, the white precipitate was collected and crystallized from alcohol to furnish 2.2 g l-benzenesulfonyl-2-benzylethylenimine as needles, in a yield of 66%, m.p., 51-53°C. 

Devise a synthesis of Apetinil, an appetite suppressant, firom each of the following starting materials, (a) l-phenyl-2-bromopropane (b) l-phenyl-2-propanone... 

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