3-Phenyl-3-bromopropan acid

Preparation 325.—jS-Phenyl-jS-Bromopropionic Acid [Z-Phenyl-Z-bromopropan add. ... 

To the solution of l-phenyl-l-methoxy-2-bromopropane methylamine was added and as a result of the reaction l-phenyl-l-methoxy-2-methylaminopropane was obtained. After that l-phenyl-l-methoxy-2-methylaminopropane on hydrolysis with hydrobromic acid yielded 1-phenyl-l-hydroxy-2-methylaminopropane, i.e. racemic pseudoephedrine. The racemic base was resolved, by crystallization of their tartrates, into I- and d-pseudoephedrine. The base l-pseudoephedrine forms white rhombic crystals, melting point 118°C. The salt pseudoephedrine sulfate may be prepeared by... 

Oxidation of the ethylene acetals of 3-aryl-3-oxo-2-propyl phenyl telluriums, which were prepared from the acetals of 3-aryl-3-oxo-2-bromopropane and arenetellurolates, with 3-chloroperoxybenzoic acid in methanol at 20° produced hydroxyethyl 2-arylpropanoates2. Tellurones were postulated as intermediates that experienced a 1,2-aryl shift and the elimination of an aryltelluro moiety. 

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