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Phenserine

Tan pathology Apoptosis Neurotransmission deficits APP production inhibitors A 3-Selective regulators Phosphatase activators GSK-3 inhibitors Cdk5 inhibitors P38 inhibitors JNK inhibitors Caspase inhibitors Neurotrophic agents Phenserine tartrate Posiphen Reticulons Chaperones/SLF-CR Axonyx Axonyx/National Institutes of Health Howard Hughes Medical Institute... [Pg.225]

Grieg NH, Pei XH, Soncrant T, Ingram DK, Brossi A, Phenserine and ring C hetero-analogues, Drug candidates for treatment of Alzheimers disease, Med Res Reviews 15 3—31, 1995. [Pg.421]

Yu QS, HoUoway HH, Flippen Anderson JL, et ai. Methyl analogues of the experimental Alzheimer drug phenserine. Synthesis and structure/activity relationships for acetyl- and butyrylchoHnesterase inhibitory action, / Chem 44 4062 071,2001. [Pg.421]

Synthesis of Heterocyclic Natural Products (-)-Ephedradine A, (-)-a-Tocopherol, (-)-Lepadin D, and (-)-Phenserine... [Pg.76]

Larry Overman also used (J. Am. Chem. Soc. 2004,126, 14043) a chiral pool starting material, but in a different way. The prochiral enolate 12 showed substantial diastereoselectivity in its reaction with the bis-triflate 13, almost 10 1. Through the power of algebra, it followed that the three diastereomers of 14 were formed in a ratio of 90 9 1. The crystalline 14 was easily isolated in diastereomerically-pure form, and carried on to phenserine 15. This is a new method for the stereocontrolled construction of chiral quaternary centers. [Pg.189]

Brossi A, Pei X-F and Greig NH (1996) Phenserine, a novel anticholinesterase related to physostigmine total synthesis and biological properties. AustJ Chem 49, 171-181. [Pg.402]

Phenserine (= (—)-A-Phenylcarbamoyl eseroline)] (phenylcarbamate) Synthetic - cl. Physostigmine AChE (carbamoylates — forms carbamoyl ester with active site Serine) [cognition enhancer for AD]... [Pg.247]

Phenserine (252), a selective inhibitor of acetylcholinesterase with minimal effect on butyrylcholinesterase, was cited as a possible anti-Alzheimer drug (319). [Pg.89]

Phenserine Acetylcholinesterase inhibitor/ beta amyloid precmsor protein inhibitor TorreyPines... [Pg.10]

Phenserine Increases neuronal differentiation of implanted human neural stem cells in mouse hippocampus and cortex [46] Rivastigmine Potential synaptotrophic effects [41]... [Pg.1337]

Shaw KT, Utsuki T, Rogers J, Yu QS, Sambamurti K, Brossi A, Ge YW, Lahiri DK, Greig NH (2001) Phenserine regulates translation of P-amyloid precursor protein mRNA by a putative interleukin-1 respraisive element a target Iot drug development. Proc Natl Acad Sci USA 98 7605-7610... [Pg.1358]

Greig NH, De Micheli E, Holloway HW, Yu QS, Utsuki T, Ptury TA, Brossi A, Ingram Die, Deutsch J, Lahiri DK, Soncrant IT (2000) The experimental Alzheimer drag phenserine preclinical pharmacokinetics and pharmacodynamics. Acta Neurol Scand Suppl 176 74—84... [Pg.1359]

Greig NH, Ruckle J, Comer P, Brownell L, Holloway HW, Flanagan DR Jr, Canfield CJ, Burford RG (2005) Anticholinesterase and pharmacokinetie profile of phenserine in healthy elderly human subjects. Curr Alzheimer Res 2 483—492... [Pg.1359]

See other pages where Phenserine is mentioned: [Pg.156]    [Pg.226]    [Pg.397]    [Pg.116]    [Pg.75]    [Pg.284]    [Pg.289]    [Pg.156]    [Pg.391]    [Pg.470]    [Pg.550]    [Pg.93]    [Pg.134]    [Pg.18]    [Pg.166]    [Pg.89]    [Pg.1336]    [Pg.1337]    [Pg.1341]    [Pg.1343]    [Pg.1358]   
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See also in sourсe #XX -- [ Pg.134 ]

See also in sourсe #XX -- [ Pg.166 ]

See also in sourсe #XX -- [ Pg.142 ]

See also in sourсe #XX -- [ Pg.238 ]



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