Phenotypes behavior

The ambiguity here is in fact one reflection of our ambiguous understanding of the details of the relations in different people between what happens to the body and what happens to the mind—that is, our ambiguous understanding of the relations between phenotype cellular toxicology and phenotype behavior. But it s a miserable fallacy to assume that because we don t know the relations in detail the relations are not important. 

The key advantage to top-down simulations of biological systems is that the process begins with the end, the full envelope of functional (phenotypic) behaviors of which an integrated biological system is capable, in mind. Top-down simulations typically begin with simple representations of the dynamics of the system phenotype, because these data are much more prevalent than data on internal states, and therefore, provide a firm foundation for guiding the development of the simulation. 

Top-down simulations follow the principle that simulations should be as simple as possible, but no simpler. The addition of detail is motivated by testing alternative hypotheses to explain key phenotypic behaviors. By contrast, in bottom-up simulations the detail is motivated by the availability of data. 

Table 2. Phenotypic Behavior of Recombinant Plasmid pAT9 in a Continuous Culture of the Transformant B. stearothermophilus CU21(pAT9) culture medium, LMPK and 48 C.

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