Phenomena Susceptible to Experiment or Computation Lone Pair Effects

Phenomena Susceptible to Experiment or Computation Lone Pair Effects 

Just one comparison is made here, that between 75 and 76, but there are many others of similar type that could be studied if preferred. 

It is here proposed that the key plausibly lies in the directionality of the Z lone pair, as in 3. If this can interact with the antibonding orbital of C=C or C=N, as in 75b or 76a, there will be an increase in the electron density of the double bond, C=C or C=N, which should increase its chemical reactivity. While C=N in 76a represents a dead end, the formation of 75b should be aided by this factor. Quantification of both reactions for Z = O, S, and NH would be valuable and could be pursued experimentally or by computation if, by the former, Z= NH would need 

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