Phenolic triterpenes

N.A. Sambucus nigra L. S. canadensis L. Flavonoids, phenolic, triterpenes, sterols, cyanogenic glycosides, vitamins A, C." Increase sweating, diuretic, antiinflammatory. 

The study of the outer root bark of T. hypoglaucum collected in China afforded three new structures of phenolic triterpenes. Duan et al. isolated triptohypol A (80), B (81) and C (82), a series of new phenolic compounds related to celastrol [29]. Triptohypol A (80) was isolated as an amorphous powder and spectroscopic means and chemical modification determined its structure. By HREIMS the formula C30H40O6 was determined, and H-NMR spectrum showed five methyl signals, a methoxy moiety, a methylene attached to an oxygen atom and two vinyl protons. Data from 13C-NMR experiments indicated the presence of a pair of carbonyl groups and was quite similar to that of wilforol A (78). The analysis of HMQC and HMBC experiments allowed to establish the structure for rings A and B, based on the correlations observed between the proton H-l (8 6.95 ppm) and the carbons C-3, C-5 and C-10. Finally, the position of the carbonyl group was established at C-6 based on a NOESY experiment of the dimethyl derivative. 

The chemical study M. amazonica roots [81] conducted to the identification of seven new phenolic triterpenes, besides the two new celastroloids discussed above. The structure of compound (83), isolated as yellow crystals, was determined by spectroscopy. HREIMS indicated a molecular formula C28H34O6, and it showed IR absorption bands for carbonyl (1685, 1720 cm 1) and hydroxyl (3550 cm 1). 13C-NMR experiments indicated a phenolic triterpene related to 6-oxo-tingenol [85]. 

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