Phenobarbitone indications

Oglialoro modification of, 708 Perkin triangle, 108, 218f Kon modification of, 109 Peroxides, detection of, in ether, 163 removal from diethyl ether, 163 removal from isopropyl alcohol, 886 Petroleum ether, purification of, 174 Phenacetin, 996, 997 1 10-Phenanthroline, 991, 992 p-Phenetidine, 997, 998 Phenetole, 665,670 Phenobarbitone, 1003,1004,1005 Phenol, 595, 613 Phenol aldehyde polymers, 1016 formation of, 1022 Phenolphthalein, 984, 985 action as indicator, 984 ... 

Feely M, Cooke J, Price D, Singleton S, Mehta A, Bradford L, et al. 1987. Low-dose phenobarbitone as an indicator of compliance with drug therapy . Br. J. Clin. Pharmacol. 24 77—83. 

In a series of careful studies, the anaesthetic effects of 30 barbiturates on the fertilised eggs and larvae of Arbacia pmctulata were quantitatively determined as a function of extra- and intracellular pH [160], The concentrations of undissociated barbituric acid derivative and its corresponding anion required to produce a 50 per cent reduction in rate of cell division of eggs and cessation of movement of larvae were calculated from the total concentrations of drug, its p/f under the conditions of the experiment, and the pH. The required concentration of undissociated species for a given compound was found to be very nearly constant over the pH range of the experiment, whereas the anion concentration varied considerably. This is exemplified in Table 3.3 for phenobarbitone pK a = 7-26). The results indicate very clearly that the barbiturates penetrate the cells only in the... 

Anticonvulsants Anticonvulsants were one of the first groups of drugs for which TDM was indicated. The common anticonvulsants encountered in clinical practice are phenobarbitone, primidone (metabolized to phenobarbitone), phenytoin, carbamazepine, ethosuximide, and valproate. The majority of assays for these drugs are immunoassays these days as 24 h availability of measurements of these drugs has become the general expectation. 

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