Phenobarbital Calcium-channel blockers

Drugs that may affect tacrolimus include nephrotoxic agents (aminoglycosides, amphotericin B, cisplatin, cyclosporine), antifungals, bromocriptine, calcium channel blockers, cimetidine, clarithromycin, danazol, diltiazem, erythromycin, methylprednisolone, metoclopramide, carbamazepine, phenobarbital, phenytoin, rifamycins, cisapride, chloramphenicol, metronidazole, nefazodone, omeprazole, protease inhibitors, macrolide antibiotics, fosphenytoin, and St. John s wort. [Pg.1938]

Drugs that may affect cyclosporine include allopurinol, amiodarone, androgens (eg, danazol, methyltestosterone), anticonvulsants (eg, carbamazepine, phenobarbital, phenytoin), azole antifungals (eg, fluconazole, ketoconazole), beta-blockers, bosentan, bromocriptine, calcium channel blockers, colchicine, oral contraceptives, corticosteroids, fluoroquinolones (eg, ciprofloxacin), foscarnet, HMG-CoA reductase inhibitors, imipenem-cilastatin, macrolide antibiotics, methotrexate, metoclopramide, nafcillin, nefazodone, orlistat, potassium-sparing diuretics, probucol, rifamycins (rifampin, rifabutin), serotonin reuptake inhibitors (SSRIs eg, fluoxetine, sertraline),... [Pg.1967]

CALCIUM CHANNEL BLOCKERS BARBITURATES L plasma concentrations of felodipine, nifedipine, nimodipine, nisoldipine and verapamil with phenobarbital Phenobarbital induces CYP3A4, which metabolizes calcium channel blockers. It also induces intestinal P-gp, which may 1 the bioavailability of verapamil Monitor PR and BP closely watch for Tbp... [Pg.86]

CYP3A4 alprazolam, calcium channel blockers, cisapride, clarithromycin, cyclosporin A, erythromycin, HIV protease inhibitors, lidocaine, midazolam, simvastatin, terfenadine carbamazepine, dexamethsone, phenobarbital, phenytoin, rifampicin, St John s wort cimetidine, erythromycin, grapefruit juice, HIV protease inhibitors, itraconazole, ketoconazole... [Pg.510]

Barbiturates, especially phenobarbital Azoles, calcium channel blockers, propranolol, quinidine, steroids, wailarin, and many other drugs metabolized in the liver Increased deararx of the affected drugs due to enzyme induction, possibly leading to decreases in drug effectiveness... [Pg.532]

Limited evidence su ests that phenobarbital greatly reduces the levels and/or increases the clearance of felodipine, nifedipine, ni-modipine, and verapamil. Other calcium-channel blockers are expected to be similar affected. [Pg.873]

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