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Verapamil monitoring

AMIODARONE CALCIUM CHANNEL BLOCKERS Risk of bradycardia, AV block and 1 BP when amiodarone coadministered with diltiazem or verapamil Additive negative inotropic and chronotropic effect. Also, amiodarone inhibits intestinal P-gp, which t the bioavailability of diltiazem and verapamil Monitor PR, BP and ECG closely watch for heart failure... [Pg.12]

CALCIUM CHANNEL BLOCKERS MACROLIDES t plasma concentrations of felodipine when co-administered with erythromycin cases of adverse effects of verapamil (bradycardia and 1 BP) with both erythromycin and clarithromycin Erythromycin inhibits CYP3A4-mediated metabolism of felodipine and verapamil. Clarithromycin and erythromycin inhibit intestinal P-gp, which may t the bioavailability of verapamil Monitor PR and BP closely watch for bradycardia and 1 BP. Consider reducing the dose of calcium channel blocker during macrolide therapy... [Pg.80]

CALCIUM CHANNEL BLOCKERS RIFAMPICIN Plasma concentrations of calcium channel blockers may be 1 by rifampicin Rifampicin induces CYP3A4-mediated metabolism of calcium channel blockers. It also induces CYP2C9-mediated metabolism of verapamil and induces intestinal P-gp, which may 1 the bioavailability of verapamil Monitor BP closely watch for 1 effect of calcium channel blockers... [Pg.80]

CALCIUM CHANNEL BLOCKERS SIROUMUS Plasma concentrations of sirolimus are t when given with diltiazem. Plasma levels of both drugs are t when verapamil and sirolimus are coadministered Diltiazem and verapamil inhibit intestinal CYP3A4, which is the main site of sirolimus metabolism Watch for side-effects of sirolimus when it is co-administered with diltiazem or verapamil monitor renal and hepatic function. Monitor PR and BP closely when sirolimus is given with verapamil... [Pg.84]

CALCIUM CHANNEL BLOCKERS ST JOHN S WORT St John s wort is associated with i verapamil levels St John s wort induces CYP3A4, which metabolizes calcium channel blockers, and induces intestinal P-gp, which may i the bioavailability of verapamil Monitor BP regularly for at least the first 2 weeks of initiating St John s wort... [Pg.85]

CALCIUM CHANNEL BLOCKERS DANTROLENE Risk of arrhythmias when diltiazem is given with intravenous dantrolene. Risk of 1 BP, myocardial depression and hyperkalaemia when verapamil is given with intravenous dantrolene Uncertain at present Extreme caution must be exercised when administering parenteral dantrolene to patients on diltiazem or verapamil. Monitor BP and cardiac rhythm closely watch for hyperkalaemia... [Pg.96]

See other pages where Verapamil monitoring is mentioned: [Pg.217]    [Pg.296]    [Pg.92]    [Pg.105]    [Pg.217]    [Pg.296]    [Pg.169]    [Pg.182]   
See also in sourсe #XX -- [ Pg.403 ]



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