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Pharmocodynamic tolerance develops in response to continued application of drugs, by mechanisms that include reversible cellular adaptation processes, such as receptor desensitization, internalization and downregu-lation as well as changes in the activity and levels of other components of the receptor s signal transduction pathways. [Pg.960]

See other pages where Pharmocodynamic Tolerance is mentioned: [Pg.960] [Pg.1499] [Pg.960] [Pg.960] [Pg.1499] [Pg.960]