Pharmacophore of 3-alkyl-5-arylimidazolidinediones

Ooms F, Wouters J, Oscari O, Happaerts T, Bouchard G, Carrupt PA, Testa B, Lambert DM (2002) Exploration of the pharmacophore of 3-alkyl-5-arylimidazolidinediones as new CBI cannabinoid receptor ligands and potential antagonists synthesis, lipophilicity, affinity, and molecular modeling. J Med Chem 45 1748-1756... 

The cannabinoid ligand can be classified according to Ooms et al [43] into six groups i) classical, ii) nonclassical, iii) bicyclic, iv) aminoalkylindoles, v) endocannabinoid analogues, vi) diarylpyrazoles. Ooms et al [43] studied the pharmacophore of 3-alkyl-5-arylimidazolidinediones as a new CBi cannabinoid receptor. Thomas et al [44] have studied SAR data on a series of 1,5-diphenylpyrazoles proposing a pharmacophoric alignment of these compounds with THC... 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ ]

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