Endocannabinoid analogues

The cannabinoid ligand can be classified according to Ooms et al [43] into six groups i) classical, ii) nonclassical, iii) bicyclic, iv) aminoalkylindoles, v) endocannabinoid analogues, vi) diarylpyrazoles. Ooms et al [43] studied the pharmacophore of 3-alkyl-5-arylimidazolidinediones as a new CBi cannabinoid receptor. Thomas et al [44] have studied SAR data on a series of 1,5-diphenylpyrazoles proposing a pharmacophoric alignment of these compounds with THC... 

Endocannabinoid analogues acting as cannabinoid receptor agonists... 

Gaetani, S., Kaye, W. FL, Cuomo, V., and Piomelli, D. (2008). Role of endocannabinoids and their analogues in obesity and eating disorders. Eat Weight Disord. 13, 42-48. 

Fowler CJ, Tiger G, Lopez-Rodriguez ML, Viso A, Ortega-Gutierrez S, Ramos JA (2003) Inhibition of fatty acid amidohydrolase, the enzyme responsible for the metabolism of the endocannabinoid anandamide, by analogues of arachidonoyl-serotonin. J Enzyme Inhib Med Chem 18 225-231... 

Jonsson KO, Vandevoorde S, Lambert DM, Tiger G, and Fowler CJ (2001) Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. Br J Pharmacol 133 1263-75. 

Finally, it should be noted also that the endocannabinoids AEA and 2-AG can be hydroxylated by 12- and 15-LOX, forming the equivalent 12-hydroxy fatty acid eth-anolamides 12-HETE-EA, 15-HETE-EA, and 12-HETE-G (Rouzer and Mamett 2011 Fonseca et al. 2013) These metabolites, like their AA analogues, have shown bioactivity though more work is needed to establish their significance (Fonseca et al. 2013). 

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