Pharmacologically active seven-membered

Amongst other examples of pharmacologically active seven-membered heterocyclic ring compounds the following are of interest 5-(2-morpholin-4-yl-ethoxy)-benzofuran-2-carboxylic acid (,S)-3-methyl-1 - 3-oxo-1 -[2-(3-pyridin-2-yl-phenyl)-ethenoyl]azepan-4-... 

Many seven-membered ring heterocyclic derivatives show pharmacological activity, and many, for example the benzodiazepines, nevirapine (anti-HIV), trineptine (antidepressant) and artemisinin derivatives (anti-malarial) are used clinically. The number of papers reporting pharmacological activity of new compounds or pharmacological mode of action studies continues at a significant rate. 

While some new spirocyclic and bridged seven-membered heterocyclic systems were reported in 2000, the scope in these two areas is significant, particularly with respect to the design of pharmacologically active compounds with new molecular architectures. Further developments in these areas are thus expected. 

Chapter 5.18 presents over 50 heterocyclic systems whose chemistry usually depends more on the nature of the heteroatoms than on the systems being seven-membered heterocycles. At the present state of knowledge, organizing the chapter in separate sections on structure, reactivity and synthesis would not produce a happy result, especially for the reactivity section. Little is presently known about the reactivities of the majority of the systems, many of which have been prepared to explore their pharmacological activities. The chapter, therefore, has been organized according to the number and nature of the heteroatoms. 

In this chapter on seven-membered rings with three heteroatoms 1,2,4, new synthetic methods, theoretical calculations, and spectroscopy are described as well as some pharmacological activities recently reported. 

J.A. G.DrakeandD. IF./oRes/NMR spectrosccqiy of tricyclic non-alternant systems containing seven-membered rings, dibenz [b, f] oxepine and dibenz [b, f] azepine parents of pharmacologically active systems 493... 

---