Pharmacologically active microcarriers

Figure 10 PAM used to improve the efficacy of cell therapies (A) Schematic Ulustration of the principle of the approach. (B and C) Optical and scanning electron micrographs of cells adhering onto PAM. Abbreviations GF, growth factor and/or cytokine PAM, pharmacologically active microcarriers. Source From Ref. 65.

Tatard VM, Venier-Julienne MC, Benoit JP, et al. In vivo evaluation of pharmacologically active microcarriers releasing NGF and conveying PC12 cells. Cell Transplant 2004 13 573-583. 

Tatard VM, Venier-Julienne MC, Saulnier P, et al. Pharmacologically active microcarriers a tool for cell therapy. Biomaterials 2005 26 3727-3737. 

Tatard VM, Sindji L, Branton JG, et al. Pharmacologically active microcarriers releasing glial cell line—derived neurotrophic factor survival and differentiation of embryonic dopaminergic neurons after grafting in hemiparkinsonian rats. Biomaterials 2007 28 1978-1988. 

Spheramine is a biological product composed of hRPE cells placed on microcarriers for implantation into the human brain. The pharmacologically active part of Spheramine is composed of the hRPE cells which produce L-DOPA. They are placed on mi-crocarriers of crosslinked porcine gelatin to enhance their survival and function. 

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