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Pharmacological response factors affecting

Both a drug s PK response and pharmacological response may be influenced by various patient characteristics. Additionally, the progression or extent of disease may be affected by comorbidities. Covariate models attempt to account for and quantify the influence of these factors. For example, a covariate model would be used in simulating PK differences between males and females. Likewise, for a disease progression model of atherosclerosis, or for the overall evaluation of... [Pg.884]

The pharmacologic principles of ligand-receptor interaction predict that the level of receptor should affect dose-response curves for enzyme induction. In rodent systems, several endogenous and exogenous factors have been shown to alter levels of various receptors or other components in the induction pathway. [Pg.172]

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Pharmacological response

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