Bromocriptine pharmacokinetics

There is no basic information on pharmacokinetics of bromocriptine in horses. Administration of 0.02mg/kg i.m. twice daily has been reported. 

Rabey, J.M., Schwartz, M., Graff, E., Harsat, A. and Vered, Y. (1991) The influence of bromocriptine on the pharmacokinetics of levodopa in Parkinson s disease. Clin. Neuro-pharmacol. 14 514-522. 

Food did not alter the pharmacokinetics of bromocriptine, cabergoline or lisuride. These dopamine agonists are usually taken with food to try and improve their tolerability. 

Kopitar Z, Vrhovac B, Povsic L, Plavsic F, Francetic I, Urbancic J. The effect of food and metoclopramide on the pharmacokinetics and side effects of bromocriptine. EurJDrugMetab Phamacokinet ( 99 ) 16, 177-81. 

Octreotide modestly increases the bioavailability of bromocriptine, whereas bromocriptine does not appear to alter octreotide pharmacokinetics. 

A study in 20 patients with Parkinson s disease taking levodopa/carbidopa found that overall there was no difference in plasma levodopa levels after bromocriptine was also taken, although some patients had either significant elevations or significant reductions in levels. However, the only adverse clinical change found was an increase in dyskinesias in the patients with elevated levodopa levels. An earlier study found no pharmacokinetic interaction between levodopa/carbidopa and bromocriptine, but it should be noted that this was a single-dose study and may not reflect long-term concurrent use. ... 

Bentue-Ferrer D, Allain H, Reymann JM, Sabouraud O, Van den Driessche J. Lack of pharmacokinetic influence on levodopa by bromocriptine. ClinNeurophannacol( 9SS) 11, 3-6. 

---