Pharmacokinetic-pharmacodynamic PK-PD modeling

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Fig. 1.3 Pharmacokinetic/pharmacodynamic (PK/PD) modeling as combination of the classic pharmacological disciplines pharmacokinetics and pharmacodynamics (from [5]).

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The times at which biological effects occur differ from those of peak systemic exposure, necessitating the use of indirect pharmacokinetic/pharmacodynamic (PK/PD) models. [Pg.81]

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