Pharmacokinetic models, biologically based compartments

Physiologically Based Pharmacokinetic (PBPK) Model—is comprised of a series of compartments representing organs or tissue groups with realistic weights and blood flows. These models require a variety of physiological information tissue volumes, blood flow rates to tissues, cardiac output, alveolar ventilation rates and, possibly membrane permeabilities. The models also utilize biochemical information such as air/blood partition coefficients, and metabolic parameters. PBPK models are also called biologically based tissue dosimetry models. 

Figure 6.1 Schematic of a simple biologically based pharmacokinetic model showing five well-stirred compartments, each with arterial and venous blood flow signified by the arrows. Chemioal flux is shown as an input to the skin compartment, and metabolism Is shown as a loss from the liver compartment.

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